GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs11706117 | chr3:134212526 | CEP63 | chr3:134204575-134293852:+ | 0.25 | 4.38 | 1.54E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs11708531 | chr3:134224902 | ANAPC13 | chr3:134196547-134204865:- | 0.5 | 7.95 | 2.1E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs11708531 | chr3:134224902 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 4.07 | 5.68E-5 | Height |
| BLCA | cis | rs12638253 | 1 | rs11712111 | chr3:156608940 | LEKR1 | chr3:156544076-156763918:+ | 0.24 | 4.61 | 5.48E-6 | Multiple sclerosis (severity) |
| BLCA | cis | rs3796352 | 1 | rs11718834 | chr3:52963668 | TMEM110 | chr3:52867139-52931547:- | 0.38 | 3.89 | 0.000117 | Immune reponse to smallpox (secreted IL-2) |
| BLCA | cis | rs11723261 | 1 | rs11722197 | chr4:281707 | ZNF718 | chr4:53272-156488:+ | 0.36 | 4.79 | 2.36E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11722521 | chr4:276765 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.66 | 4.33E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11723261 | chr4:282499 | ZNF718 | chr4:53272-156488:+ | 0.36 | 4.79 | 2.36E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11723615 | chr4:276983 | ZNF718 | chr4:53272-156488:+ | 0.35 | 4.77 | 2.6E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11723803 | chr4:292369 | ZNF718 | chr4:53272-156488:+ | 0.26 | 4.02 | 6.87E-5 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11724176 | chr4:224901 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.49 | 9.44E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11724417 | chr4:223352 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.49 | 9.44E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11729365 | chr4:272524 | ZNF718 | chr4:53272-156488:+ | 0.35 | 4.73 | 3.22E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs798766 | 1 | rs11729657 | chr4:1737585 | FAM53A | chr4:1641609-1685854:- | -0.31 | -4.5 | 9.09E-6 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs11723261 | 1 | rs11730202 | chr4:210096 | ZNF718 | chr4:53272-156488:+ | 0.32 | 4.33 | 1.95E-5 | Immune response to smallpox vaccine (IL-6) |